Offres & annonces

PhD How do Actinomyces Coordinate Secondary Metabolite Production in Response to their Environment?

16/07/2015
Now accepting applications from 4 June till 16 July 2015!
All eligible candidates must fulfill the formal requirements outlined in the application procedure.
Attention deadline  aujourd'hui 16 juillet 2015

Directeur de thèse : Dieter Spiteller - Chemical Ecology and Chemical Biology

How do Actinomyces Coordinate Secondary Metabolite Production in Response to their Environment?

Actinomyces bacteria are invaluable due to their highly diverse secondary metabolites. Many of which are used in medicine, e.g. as antibiotics. From genome sequencing it became evident that Actinomyces possess many more gene clusters for secondary metabolite production than products have been identified from them. Under usual laboratory conditions Actinomyces obviously have no need to produce all these compounds whereas under particular conditions it can be expected that most of these compounds are produced in response to certain environmental challenges. 

This project aims to reveal how Actinomyces react to environmental factors, e.g. heavy metal ion stress or cocultivation with other organisms. Using differential metabolite profiling the differences in secondary metabolim between varying growth conditions will be revealed. Induced secondary metabolites will be identified using a combination of mass spetrometry, NMR and genome mining. The biological function of identified metabolites will be studied in appropriate bioassays. In addition, the pharmaceutical value of newly identified compounds will be investigated. Moreover, the molecular basis of factors leading to the induced production of secondary metabolites should be addressed.

We will follow an interdisciplinary approach combining techniques of microbiology, genome mining and analytical chemistry, Therefore, a stron interest and background in natural products chemistry, analytical chemistry (mass spectrometry and NMR) and/or genome mining is required.

The project is funded by a fellowship.

How to Apply

Four steps to your application: REGISTER › LOG IN › UPLOAD › SUBMIT

1) REGISTER with our online application platform. Once you registered you will receive a confirmation email to install your personal account.

2) LOG IN to work on your application, please fill in your contact data and provide the following:
A maximum of three PhD projects you are interested in, chosen from the list of projects and ranked by your preference
A motivation letter (max. 500 words)
Contact details for two academic references (please note that we will contact them during the application process ourself)
State where the call came first to your attention.

3) UPLOAD the following documents (in English or German):
Curriculum vitae (only accepted in chronological order)
Copy of your bachelor's and master's degree certificates (or equivalent) incl. transcripts of records
Proven proficiency in English: at least level B2 of the Common European Framework of Reference for Languages is required (Here you can find detailed information on acccepted certificates).

4) SUBMIT your application until 16 July 2015 at the latest!
Applications are only accepted via our online application platform ( https://korscb.glowbase.com/login)

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