Offres & annonces

PhD MODELING OF MAMMALIAN CELL METABOLISM - Prague

16/07/2015
Source : euraxess
Job posted by VSCHT Praha (13/07/2015 09.23) 
Main goal of the project is to understand the metabolism of mammalian cell under various operating conditions and consequent optimization of the feeding strategy.

Project is a part of large initiative to understand mammalian cell metabolism and its change under various conditions. Student will be responsible for the modelling of cell metabolism using various techniques including Metabolic Balance Analysis and Flux Balance Analysis. 
Extracellular fluxes will be calculated from the time evolution of the carbon and nitrogen sources such as glucose, glutamine, lactate as well as all amino acids using HPLC. In parallel to this technique for selected conditions LC-MS method will be used to gain knowledge about the concentration of several intracellular components. When combined with the specific consumption of labeled isotope 13C (various carbon sources) and 15N (nitrogen containing amino acids), this method could be used for validation of the intracellular fluxes calculated by the developed model. Once validated such model will be used to optimize feeding strategy for fed-batch and perfusion cultivation.

Nr of positions available : 1

Research Fields

Engineering - Chemical engineering

Career Stage

Early stage researcher or 0-4 yrs (Post graduate) 

Research Profiles

First Stage Researcher (R1) 

Comment/web site for additional job details

Project will be realized in a collaboration with industrial partner.

Requirements

Required Education Level 
Degree Field Engineering 
Degree Master Degree or equivalent 
Additional Requirements 
- good modeling capabilities (MATLAB, FORTRAN or equivalent)
- understanding of cell metabolism modeling
- successful candidate will be dynamic, motivated and outgoing student with excellent interpersonal skills 

VSCHT Praha

Department of chemical engineering
Academic
Technicka 5
166 28 - Prague
CZECH REPUBLIC
email miroslav.soos@vscht.czhttp://fchi.vscht.cz/research/soos 
Envisaged Job Starting Date: 01/10/2015 
Application Deadline: 28/08/2015 
Application e-mail: miroslav.soos@vscht.cz 

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